Assessment of Circulating Biochemical Markers and Antioxidative Status in patients suffering from Melasma

Human phenotype including skin colour patterns is associated with genetic, evolutional as well as cultural aspects which rely on production of melanin. Melasma is crucial disorder related to the skin that affects the population. The aim of this study was to evaluate the various contributing circulating biochemical markers that could be responsible for melasma. Fifty (50) patients suffering from melasma and twenty (20) clinically healthy individuals were selected for this study. Lipid profile as well as oxidative and anti-oxidative profiles was estimated in patients and healthy individuals. HDL was decreased in patients (1.39±0.10*) as compared to control (1.73±0.17) group. On contrary, TCh (5.48±0.92*), Tg (2.59±0.53*), and LDL (2.48±0.23*) were raised in patients. Alterations in lipid profile were statistically significant (P<0.05). Malondialdehyde (MDA) was elevated (5.44±1.14*) in patients while anti-oxidative parameters were decreased in patients and all were statistically significant (P<0.05). It can be concluded that not only the melanin but also other circulating biomarkers like cholesterol, Tg, HDL and LDL may be the contributing factors for the progression of melasma. Moreover, oxidative stress markers may also be used in disease prognosis and diagnosis.